What Comes After BioCell? Exploring the Next Generation of Collagen Formulas

Modere helped usher collagen into the mainstream wellness conversation. With its patented BioCell Collagen formula, the company carved out a strong reputation among consumers looking to support skin hydration, joint function, and overall mobility. For years, BioCell served as the best collagen for women and men seeking noticeable anti-aging results without invasive procedures or synthetic ingredients.

But as of April 2025, Modere is no longer in business, a closure that has left many loyal customers searching for a replacement. BioCell was part of a lifestyle supported by a larger ecosystem of health-conscious routines and peer-to-peer distribution. With its absence, the collagen supplement market is undergoing a period of transition. Consumers are asking: What now?

The answer may lie in the next generation of collagen formulations, those that go beyond beauty to also support metabolic health, cognitive clarity, and digestive balance. One such standout is CollagenB3 from Sisel International, a science-backed blend that reflects where the collagen category is headed. While BioCell laid the foundation, today’s wellness community is demanding more from their supplements, and some brands are rising to the occasion.

Modere and BioCell: Setting the Benchmark

For a time, Modere’s BioCell Collagen was considered a gold standard. The formula addressed multiple signs of aging from within — namely, skin dryness, joint stiffness, and the decline in elasticity that naturally comes with age by combining hydrolyzed Type II collagen with hyaluronic acid and chondroitin sulfate. This multi-benefit approach made BioCell a trusted favorite across a wide consumer base, especially among women seeking the best collagen for skin, hair, and nails without compromising on ingredient integrity.

Beyond the product itself, Modere’s modern approach to direct selling also helped elevate its brand. With a clean aesthetic, influencer-friendly packaging, and social-media-savvy outreach, it attracted younger demographics and wellness enthusiasts who might have previously avoided MLMs. In many ways, Modere redefined what a direct sales brand could look like in the digital age.

However, even strong product legacy and marketing innovation couldn’t shield the company from larger business challenges. While details around the closure remain limited, it reflects a broader truth in the industry: consumer expectations are shifting, and companies must innovate in branding and formulation. As the dust settles, the question isn’t just who will replace BioCell — it’s who will lead collagen innovation into the next decade.

The Market Shift: What Today’s Consumers Want from Collagen

In the wake of Modere’s exit, the collagen supplement landscape is evolving rapidly. Today’s wellness-conscious consumer isn’t just seeking surface-level benefits like smoother skin or shinier hair. They’re looking for formulas that do more, supporting the entire body, from brain to bones. Collagen is no longer seen as a one-dimensional beauty booster, but as a foundational protein that plays a role in skin health, joint mobility, cognitive function, and even metabolic balance.

This shift is driving demand for multi-source collagen formulas, products that combine various types of collagen (most often Types I, II, and III) to provide broader benefits. Where BioCell was once enough, consumers now expect collagen products to support energy, focus, digestion, and immunity.

Add to that the growing preference for clean ingredients, science-forward formulations, and functional blends, and it’s clear why outdated products are falling out of favor. Shoppers are turning their attention to brands that embrace innovation and transparency, especially those offering collagen supplements with bonus benefits like MCT oil for cognitive support or hyaluronic acid for skin hydration.

Sisel’s Answer: CollagenB3 as the New Standard

Enter CollagenB3 by Sisel International, a comprehensive collagen supplement engineered for the next generation of wellness seekers. Unlike many single-source formulas, CollagenB3 blends three types of collagen (Types I, II, and III) with a powerful mix of functional ingredients that amplify its benefits across multiple systems in the body.

• Type I and III Collagen are foundational for healthy skin, strong nails, and resilient hair.
• Type II Collagen supports joint flexibility and cartilage strength.
• Hyaluronic Acid adds hydration, plumping the skin and reducing the appearance of fine lines.
• MCT Oil acts as brain fuel, promoting mental clarity and sustained energy, an uncommon but highly desirable benefit in a collagen product.
• Chaga, Cordyceps, Biotin, and L-Tryptophan support immune function, stress relief, and mood balance, making this formula a true mind-body solution.

What truly sets CollagenB3 apart isn’t just the variety of ingredients — it’s the potency and transparency behind them. While many popular collagen products contain just 3–7 grams per serving and hide their actual amounts behind proprietary blends (as seen with BioCell), CollagenB3 delivers over 20 grams of collagen per serving. That means real, functional amounts designed to drive noticeable results.

This is a whole-body wellness product designed for women and men who want more from their supplements. Whether your goals include supporting hair, skin, and nails, improving joint resilience, or fueling your mind through MCT-derived ketones, CollagenB3 delivers on multiple fronts.

Sisel’s in-house manufacturing ensures quality control at every stage, and the formula aligns with the brand’s longstanding commitment to clean, effective, toxin-free products. With consumer expectations shifting toward multifunctional nutrition, CollagenB3 isn’t just filling the void left by BioCell — it’s elevating the category entirely.

Direct Sales Done Right: Sisel vs. Other MLM Models

Modere may have modernized the look and feel of direct sales, but the industry still battles perceptions of inflated prices, overhyped products, and underwhelming support. As consumers become more informed, transparency and value are more important than ever. That’s where Sisel International sets itself apart, not only through innovation but through infrastructure, leadership, and integrity.

Unlike many MLM companies that rely on third-party manufacturers, Sisel formulates, manufactures, and packages all of its products in-house at a 300,000-square-foot facility. This vertical integration gives the company full control over product quality and safety, ensuring that what goes into each supplement reflects the brand’s non-toxic, science-backed mission. It also reduces middleman costs, allowing Sisel to deliver more value and higher-quality ingredients at a better price.

Sisel also offers what is widely considered one of the most lucrative compensation plans in the industry. With up to eight profit centers and higher payouts than many legacy companies, Sisel empowers its distributors in ways that Modere and others often fall short. While some companies push rapid recruitment with minimal support, Sisel focuses on long-term success through education, mentorship, and genuine product belief. The company’s four-year streak of consistent sales growth, culminating in a 94.4% increase from 2021 to 2024, speaks volumes about its sustainable momentum​.

Sisel’s commitment to clean science, ethical practices, and distributor support reflects what today’s consumer and entrepreneur are looking for in a direct sales partner. The closure of Modere marks a cautionary tale, but Sisel’s steady rise illustrates how thoughtful business strategy and innovation can create a lasting impact.

The Future of Collagen Is Here

Modere helped bring collagen into the spotlight, but the spotlight has since widened. Today’s consumers are looking beyond single-function supplements toward smart, synergistic solutions that deliver more for their money and their health. As BioCell exits the market with Modere’s closure, the door is open for a new generation of wellness-focused formulas to take its place.

Sisel’s CollagenB3 stands out not only as a worthy successor but also as a product designed for what’s next. By combining multi-source collagen with MCT oil, hyaluronic acid, and targeted botanicals, it supports skin elasticity, joint health, and cognitive clarity in one clean, science-forward blend. It’s the kind of formulation that reflects where the market is going and why savvy consumers are making the switch.

For those still wondering where to go after BioCell, the answer isn’t just about replacing a product—it’s about upgrading to a smarter approach. The next chapter of collagen innovation is already here, and it’s built for beauty, body, and brain.